Safe, reliable and FDA approved—for precise induction of ovulation

Efficacy Studies

Study 1
Compared efficacy of deslorelin acetate at concentrations of 0.45, 0.9, 1.35 and 1.8 mg/mL with each group compared to placebo. There were 10 mares per treatment arm.

Treatment Group Ovulation by
48 hours
Placebo 20%
SucroMate™ 1.0 mL 90%

Conclusion
The 1.0 mL SucroMate™ dose (1.8 mg/mL deslorelin acetate) was the most effective for advancing ovulation to within 48 hours following treatment.


Study 2
A second study confirmed that 1.8 mg/mL SucroMate™ was more effective in advancing ovulation compared to a
0.9 mg/mL dose and a 1.35 mg/mL dose.

Treatment Group Ovulation by
48 hours
Placebo 0% (0/12)
SucroMate™ 1.0 mL 82% (9/11)

Conclusion
The 1.0 mL SucroMate™ dose (1.8 mg/mL deslorelin acetate) was the most effective for advancing ovulation to within 48 hours following treatment. There was no detrimental effect on the cycle of administering SucroMate™ on 3 consecutive cycles.


Study 3: Field Based Safety and Efficacy Study

  • A six site, blinded, controlled, multi-centered field efficacy study.
  • Mares were randomly assigned into two groups: a single injection of either 1.0 mL of either saline or
    1.0 mL SucroMate™ (1.8 mg/mL deslorelin acetate).
  • Breeds included: 23 (8%) Standardbreds, 159 (56%) Thoroughbreds, 98 (35%) Quarter horses and 3 (1%) Paint horses.
  • Route of administration: Intramuscularly into the fleshy part of the neck using an 18–21 gage needle.
  • Parameters measured: percentage of mares ovulating within 48 hours following injection, as measured by ultrasound per rectum.
  • Time to ovulation was calculated from day of treatment to day of ovulation in 24hr increments
  • Additional parameters measured: Percentage of mares that became pregnant following treatment and breeding in any ovulatory period. Mares were followed through gestation and all normal and abnormal deliveries were recorded.
  • The number of estrus cycles required for mares to become pregnant was recorded.
  • Injection sites were examined for signs of swelling, sensitivity to touch and skin temperature elevation daily for the first 7 days and then at 14 and 21 days post treatment.

Efficacy Results

Treatment Group No. Cycles No. Mares Ovulated
by 48 hours
Placebo 131 97 27%
SucroMate™ 142 94 77%

Safety Results
There was no sensitivity to the touch nor increase in skin temperature observed at any injection site in either the placebo or SucroMate™ treated mares in any cycle.

Slight swelling occurred in the injection site in 3 mares in each treatment group on day 1 in Cycle 1 and 1 mare
on days 0 and 3 in Cycle 2.



Additional Studies
Efficacy of Deslorelin Acetate (SucroMate) on Induction of Ovulation in American Quarter Horse Mares